Nicotinamide Adenine Dinucleotide is a widely known coenzyme for inducing the production of cellular energy. It resides in the mitochondria of every living cell and is a primary contributor to many essential reactions and body functions. The effect of NAD+ on the process of aging is studied upon by a group of researchers from the University of New South Wales. Read on below to know the findings of the study.
How does NAD+ fight against oxidative stress?
Oxidative stress is the name of a notorious factor which speeds up the aging cycle. The mechanism behind the formation of this factor is that when our consumed food intake is converted into useful energy, it also forms a harmful byproduct known as free radical. These free radicals accumulate all throughout the body as we age. This byproduct causes damage to the cells and reduces cellular functions. If the cells are not allowed to function effectively, it will ultimately lead to the impairment of organs. When we are young, the body can battle the free radicals immediately with the help of antioxidants. However, in old age this physiological ability is lost due to the unequal balance of antioxidants and free radicals. This unbalance not only causes aging but it harms the cell membranes, proteins and DNA.
Due to these reasons, it is agreed by all scientists that when free radicals are in excess, aging will start and health will deteriorate. Therefore, the research from the university aims to show a link between oxidative stress and NAD+. By determining a link, it will be proven that NAD has importance in slowing down aging. For the study, skin samples were taken and they were tested to see if NAD levels have an influence on the age-related physiological decline.
- Oxidative DNA damage
By testing the skin from the samples, it is clarified that the free radicals damage the structure of DNA which kills the cells. Moreover, mutagenesis can also be induced by oxidative stress in which the genetic information is changed.
Free radicals create oxidative stress in the lipids which is known as lipid peroxidation. In this condition, lipids are damaged.
Results of study
This study reveals the results that with the progression of age, NAD decreases in amount. This leads to an increase in oxidation in various organs especially lipids. In men, the lipids oxidation elevates with age. The damage of DNA is also a result of age. The proteins which regulate the cells and their efficacy are known as Sirtuins. These proteins reduce in number as age increases which causes the cells to be impaired and die. On the other hand, the proteins which are responsible for the programmed cell death get higher in amount.
Therefore, it is necessary to regulate the levels of NAD in order to fight aging. This is because as the decrease of NAD occurs, physiological decline, impairment of organs and cellular damage gets initiated. These all factors are strong enough to cause the aging symptoms. The physical symptoms of aging visible on the skin can be prevented by Renue Lotion and NAD+ lotion Alivebyscience.com.